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KMID : 1035620130010040295
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Allergy Asthma & Respiratory Disease
2013 Volume.1 No. 4 p.295 ~ p.302
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Updates on desensitization for hypersensitivity reactions related to chemotherapy
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Lee Suh-Young
Yang Min-Suk
Jung Jae-Woo
Oh Mi-Jung
Park Chang-Han
Sohn Seong-Wook
Kang Hye-Ryun
Cho Young-Joo
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Abstract
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As the use of chemotherapeutic agents increased rapidly in recent years, more patients are under the potential risk of chemotherapy related adverse reactions. Multiple regular exposures to the same drug by chemotherapy protocol may increase the risk of sensitization to a chemotherapeutic agent, which can result in hypersensitivity reactions. Once severe hypersensitivity reactions occur, causative drugs should be avoided. However, a substitute with equal efficacy is not always available. When there is no effective alternative, desensitization is a safe tool for maintenance of chemotherapeutic agents causing hypersensitivity reaction. In this review, we introduce the latest knowledge about desensitization protocol for chemotherapeutic agents which are frequently used recently.
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KEYWORD
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Immunologic desensitization, Antineoplastic agents, Drug hypersensitivity
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